【摘 要】
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In humans,substances use during adolescence increases the risk of psychiatric disorders and drug addiction in adulthood.Adolescence represents a critical period for maturation of the brain.Thus,adoles
【机 构】
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Nanjing Medical University, Nanjing University of Chinese Medicine, Nanjing, 210023
【出 处】
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第十四届全国药物依赖性学术会议暨国际精神疾病研讨会
论文部分内容阅读
In humans,substances use during adolescence increases the risk of psychiatric disorders and drug addiction in adulthood.Adolescence represents a critical period for maturation of the brain.Thus,adolescent brain is more sensitive to neurobiological changes induced by internal or external stimuli,such as drug abuse.Prefrontal cortex (PFC) and hippocampus (HP) play important roles in cognition,emotion and decision making,and have been highly implicated in development of addiction and mental disorders.The present study is to investigate the morphological,neurochemical and functional changes in adult PFC and HP that may be induced by adolescent cocaine exposure.Furthermore,the impaired responses to stress in adult animals by an adolescent cocaine-exposed history have been also examined using behavioral tests and fMRI.These preliminary results suggest that substance use during early life may lead to deficits in the development and function of brain,and ultimately contribute to the abnormal behaviors in the later life.
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