内质网应激状态下Nrf2细胞防御系统的激活及其对斑马鱼肝脏发育的影响

来源 :第三届全国斑马鱼研究大会 | 被引量 : 0次 | 上传用户：zl74531

【摘要】

：

　　有害物质和细胞压力在人体内的聚积，直接危害人类的健康.生物体通常会通过细胞防御系统的激活来对抗，减少机体损伤.Nrf2－Keap1 系统是一个非常重要细胞防御保护系统，它能对多

【作者】

：

李丽小林麻己人

【机构】

：

哈尔滨工业大学生命科学院日本筑波大学医学院

【出处】

：

第三届全国斑马鱼研究大会

【发表日期】

：

2013年10期

【关键词】

：

先天性糖基化紊乱综合征 Nrf2生体防御系统内质网应激斑马鱼

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　　有害物质和细胞压力在人体内的聚积，直接危害人类的健康.生物体通常会通过细胞防御系统的激活来对抗，减少机体损伤.Nrf2－Keap1 系统是一个非常重要细胞防御保护系统，它能对多种环境因子做出应答，启动抗氧化蛋白元件，调控抗氧化蛋白和Ⅱ相解毒酶的表达，在细胞的防御保护中发挥重要作用.Nrf2 系统在脊椎类动物中高度保存，在进行Nrf2 活性表达异常的人工变异斑马鱼筛选实验中，我们发现一组变异系统(it768).该系统在无任何外来刺激状下，仍可将Nrf2系统激活.证明了内在性的刺激对Nrf2 系统的作用.进一步的研究证明，这种内在性的刺激为内质网应激反应.

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内质网应激状态下Nrf2细胞防御系统的激活及其对斑马鱼肝脏发育的影响

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