【摘 要】
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Objective:To investigate the relationship between magnetic resonance imaging(MRI)manifestations and level of consciousness,and find regions or networks which can act as biomarkers for consciousness le
【机 构】
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Department of Radiology,Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University
【出 处】
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中华放射学学术大会2016、中华医学会第23次全国放射学学术大会暨中华医学会第24次全国影像技术学术大会
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Objective:To investigate the relationship between magnetic resonance imaging(MRI)manifestations and level of consciousness,and find regions or networks which can act as biomarkers for consciousness level and recovery outcome in patients with disorders of consciousness.Methods:Selecting Data of MRI manifestations of patients with brain injury at Department of Neurosurgery,Nanjing Drum Tower Hospital,from 2013 to 2015,analyzing the relationship their MRI manifestations and level of consciousness in all patients,and functional connectivity strength(FCS)of resting state networks and consciousness level and recovery outcome in patients with disorders of consciousness.Results:A total of 19 patients out of 36 cases were with disorders of consciousness,their MRI results show the rate of lesions in corpus callosum,the medial prefrontal and brainstem is higher than conscious patients.From resting state functional MRI results,we found decreased FCS with loss of consciousness primarily distributed in Default mode network(DMN)and Executive control network(ECN).The FCS values of left inferior temporal and parietal gyrus,which belong to the ECN were significantly correlatedwith consciousness level,and the FCS values of precuneus,a part of DMN,was corrected with recovery outcome.Conclusion:In conclusion,patients with lesions in corpus callosum,medial prefrontal cortexand brainstemare easily resulted in unconsciousness.Our results also indicate that functional connectivity strengths of ECN and DMNcould serve as indicators for consciousness level and recovery outcome in patients with disorders of consciousness.
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