Co-delivery of siRNA and docetaxel into tumor by polypeptide micelles based on PEG-PLL-PLLeu tribloc

来源 :International Conference on Nanoscience & Technology,China 2 | 被引量 : 0次 | 上传用户：dysongbo

【摘要】

：

【作者】

：

Cuifang Zheng Huqiang Yi Mingbin Zheng Ping Gong Guolin Li Pengfei Zhang Lintao Cai

【机构】

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CAS Key Lab of Health Informatics,Guangdong Key Laboratory of Nanomedicine,Shenzhen Key Laboratory o

【出处】

：

International Conference on Nanoscience & Technology,China 2

【发表日期】

：

2013年3期

【关键词】

：

siRNA Docetaxel Polypeptide Co-delivery

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　　Combination of two or more therapeutic strategies with different mechanisms can cooperatively impede cancer development.Codelivery of chemotherapeutic drug and small interfering RNA (siRNA) within a single nanoparticle provides a rational strategy for combined cancer therapy.Here, we prepared polypeptide micelle nanoparticles (NP) of a triblock copolymer poly(ethylene glycol)-b-poly(L-lysine)-b-poly(L-leucine) (PEG-PLL-PLLeu) to systemically eodeliver docetaxel (DTX) and siRNA-Bcl-2 for an effective drug/gene vector.

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Co-delivery of siRNA and docetaxel into tumor by polypeptide micelles based on PEG-PLL-PLLeu tribloc

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