【摘 要】
：
RNA nanotechnology encompasses the use of RNA as a construction material to build homogeneous nanostructures by bottom-up self-assembly into defined size, structure, and stoichiometry. Recently, we re
【机 构】
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Nanobiotechnology Center, Markey Cancer Center,College of Pharmacy, University of Kentucky, USA
【出 处】
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The 6th International Conference on Nanoscience and Technolo
论文部分内容阅读
RNA nanotechnology encompasses the use of RNA as a construction material to build homogeneous nanostructures by bottom-up self-assembly into defined size, structure, and stoichiometry. Recently, we reported the finding that RNA can serve as the building block of polymer materials for the construction of boiling-resistant architectures with applications in medicine, immunology, cancer therapeutics, material sciences, single molecule optics, electronics and computer devices. Our platform is based on the packaging RNA (pRNA) of bacteriophage phi29 DNA packaging motor. The pRNA is a versatile molecule for constructing multivalent 3D architectures with diverse sizes and shapes via loop-loop (hand-in-hand) interactions; palindrome sequences (foot-foot-interactions); and three-way junction motif (3WJ) motif. These RNA nanoparticles are thermodynamically stable, resistant to RNase degradation, and can harbor resourceful functionalities.
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