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Genes that exhibit differential expression behaviors are called pattern genes (Pan et al.,2012).Four kinds of pattern genes include housekeeping gene (HKgene),specific gene (Spgene),selective gene (Segene) and repressed gene (Regene).Co-expression phenomena of neighboring genes have been studied and explained by factors such as the existence of operons,gene-function correlation,inter-gene physical distance,sharing similar regulatory elements,and modulation of chromatin conformation.