Hi-C相关论文
精原干细胞（spermatogonial stem cells,SSCs）具有自我更新与分化的双向潜能,维持哺乳动物精原干细胞池的稳定以及源源不断的精子产......
小构树（Broussonetia monoica）属于桑科构属,为直立或披散灌木,分布于中国长江中下游及以南各地。作为重要的造纸原料和药用植物,对......
会议
前列腺癌在全球男性中发病率居于前列,遗传因素是影响前列腺癌发生发展的主要因素.研究报道1号染色体长臂42区3带至43区(1q42.3-43......
[目的]冬虫夏草Ophiocordyceps sinensis是一种重要的食药用真菌,仅分布在青藏高原及其周边高海拔地区,具有独特的生存环境、生物......
染色质交互作用是不同染色质间发生的交互现象,影响基因遗传调控等机制。染色质交互作用测量的人工实验成本很高精度很低,且难以在......
染色体Hi-C技术的提出与快速发展,让人们能精确的获取到染色体三维空间位置结构的信息,但是如何通过Hi-C数据来发现更多生物意义以......
Chromosomes in eukaryotic cell nuclei are highly compacted and finely organized into hierarchical three-dimensional (3D)......
细胞核是真核细胞内最大的细胞器,是基因组的储存场所,是一种严格区室化高度不均一的亚细胞结构。染色质是基因组的存在形式,是细......
近年来,随着高通量染色体构象捕获(Hi-C)等技术的发展和高通量测序成本的降低,全基因组交互作用的数据量快速增长,交互作用图谱分......
It is known that chromatin three-dimensional (3D) structure plays important roles in nucleus.Recently,the extensive work......
Background: Higher-order chromatin structure of eukaryotes is a key regulator of gene transcription in a long range[1].B......
Background: Trans-eQTL can affect the expression of distal gene by inter or intra-chromosomal interaction, which may giv......
Background: More than 90 percent of the human genome is non-coding sequence.However,only a small number of these regions......
Background: Various aspects of genome organization have been explored based on data from distinct technologies, includin......
Introduction:Genome sequence plays an important role in both basic and applied studies.Gossypium raimondii,the putative ......
Characteristic arrangement of nucleosomes is predictive of chromatin interactions at kilobase resolu
High throughput chromosome conformation capture technologies such as Hi-C,have made it possible to survey the 3D gen......
In this manuscript,we will present two related studies on decoding human genome with 3D chromatin interaction data.I......
One of the new sequencing technique is the so called Hi-C(High-throughput Chromosome Conformation Capture).It aims t......
The spatial arrangement of chromosomes in the nucleus is important for gene expression and genome function both in a......
3Disease Browser A Web server for integrating 3D genome and disease-associated chromosome rearrangem
Chromosomal rearrangement (CR) events have been implicated in many tumor and non-tumor human diseases.CR events lead to ......
Characteristic arrangement of nucleosomes is predictive of chromatin interactions at kilobase resolu
To obtain kilobase resolution chromatin interactions at low cost remains a major challenge.We present algorithms,named C......
Background: The chromosome conformation capture (3C) derived techniques, such as 4C, 5C, ChIA-PET and Hi-C, have rev......
Analysis of gene location relative to chromosome loops and topological chromosome domains by ChIA-PE
Several technologies based on chromatin immunoprecipitation (ChIP) have been developed to study the binding of transcrip......
研究背景:慢性肾小球肾炎(chronic glomerulonephritis,CGN)的病人发病时间不固定,早期症状不明显。患者肾脏中肾小球持续缓慢累积......
在三维基因组领域,Hi-C技术在研究全基因组交互中扮演关键角色。随着技术的进步,传统Hi-C实验中的数据利用率低,实验周期长,实验成......
肝癌是指发生于肝脏细胞的恶性肿瘤,全球每年新发肝癌病例84.1万,新增死亡病例78.2万,严重威胁人类健康。肝癌的治疗方法主要为外......
罗布麻(Apocynum venetum),又名红麻,夹竹桃科(Apocynaceae)多年生宿根草本植物,是我国宝贵的野生植物资源,作为抗逆性极强的生态......
HPV-CCDC106 integration alters local chromosome architecture and hijacks an enhancer by three-dimens
Integration of human papillomavirus(HPV)DNA into the human genome is a reputed key driver of cervical cancer.However,the......
Gelsemium elegans (G.elegans) (2n =2x =16) is genus of flowering plants belonging to the Gelsemicaeae family.Here,a high......
Background:Although significant progress has been made to map chromatin structure at unprecedented resolution and scales......
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The spatial organization of the genome plays an important role in the regulation of gene expression.However,the core str......
本文通过对荣华二采区10...
染色体是由核苷酸序列排列而成,并通过折叠盘旋形成一定的空间结构。染色体在折叠盘旋时相互接触形成调控因子,调控生物体的各项生......
真核生物的染色体如何发生复杂构象变化并组织成复杂的高级结构,仍是一个研究热点。染色体的这些结构特征和构象变化可通过了解染......
小叶杨是杨属中的重要树种,其广泛分布于北半球并且有着悠久的栽培历史。它是我国三北地区的重要树种,在防治荒漠化、减少水土流失......
基于染色体构象捕获技术及其衍生技术(如Hi-C)的研究表明,染色质高阶结构在转录调控、DNA复制、早期胚胎发育以及疾病发生等过程中......
植物开花性状受多基因共同调控,其深入分析对清楚认识开花机制,了解生物功能,提高经济作物产量以及改良轮作制度都具有重要意义。......
十字花科芸薹属物种中包含了许多蔬菜以及油料作物,包括我们常见的白菜、甘蓝、芥菜和油菜。同时,芸薹属物种在进化过程中经历过数......
Objective:Monoamine system plays a key role in the pathophysiology of a wide range of neuropsychiatric disorders includi......
回 回 产卜爹仇贱回——回 日E回。”。回祖 一回“。回干 肉果幻中 N_。NH lP7-ewwe--一”＄ MN。W;- __._——————》 砧叫]们......
染色体的空间交互作用被视为影响基因表达调控的重要因素,高通量染色体构象捕获(high-throughput chromosome conformation captur......
基因组三维结构在DNA复制、DNA损伤修复、基因转录调控中扮演着重要的角色。Hi-C是目前研究基因组三维结构的主要手段之一,但是存......
染色质高级结构是基因转录调节的重要因素，染色质多重相互作用是高级结构中的一种，是多个（≥3）染色质片段在空间上相互接触而形成的紧......
ue＊M＃’＃dkB4＃＃8＃”专利申请号:00109“7公开号:1278062申请日:00.06.23公开日:00.12.27申请人地址:（100084川C京市海淀区清华园申请人:清......
近20年来,研究者们通过大规模DNA测序,在基因组、转录组和表观基因组方面获得了大量的信息,这些信息为人类基因组中的功能元件和相......
