【摘 要】
：
In renal cell carcinoma (RCC), HKLA class Ⅰ down regulation has been found in 40% of the tumor lesions examined.Since only scanty information is available regarding the molecular basis of these defect
【机 构】
：
Graduate Institute of Clinical Medical Sciences Chang Gung University Taoyuan Taiwan
【出 处】
：
BIT‘s2nd Annual World Cancer Congess-2009 (2009第二届癌症大会)
论文部分内容阅读
In renal cell carcinoma (RCC), HKLA class Ⅰ down regulation has been found in 40% of the tumor lesions examined.Since only scanty information is available regarding the molecular basis of these defects, we have investigated the mechanism underlying HLA class Ⅰ antigen down regulation or loss in six RCC cell lines.Five of them express HLA class Ⅰ antigens although at various levels.On the other hand, HLA class Ⅰ antigens were not detectable on the remaining cell lines, the RCC52 cell line belonging to a sarcomatoid subtype, even following incubation with IFN-γ.β2 microglobulin (β2m) was not detected in RCC52 cells.Surprisingly, RCC52 cells harbor two mutations in the β2m genes in exon 1: a single G deletion (delG) in codon 6, which introduces a premature stop codon 7, and a CT dinucleotide deletion (delCT), which leads to a premature stop at codon 55.Analysis of eight clonal sublines from the RCC52 cell line showed that the two β2m gene mutations are carried separately by RCC cell subpopulations.
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