Meiotic prophase I defects in an oligospermic man with Wolf-Hirschhorn syndrome with ring chromosome

来源 :GTAUF2014 & APSMHA2014第六届长城泌尿男科转化医学论坛暨第七届亚太男性健康与抗衰老研究学会年会 | 被引量 : 0次 | 上传用户：enhanyi

【摘要】

：

Background: Ring chromosomes are often associated with spermatogenetic failure.However, the mechanism is poorly understood.We here reported a single man with severe oligospermia and a ring chromosome

【作者】

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Qi Yao Liu Wang Bing Yao Hongliu Gao Weiwei Li Xinyi Xia Qinghua Shi Yingxia Cui

【机构】

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The Institute of Reproductive Medicine, Jinling Hospital, Nanjing University School of Medicine, Nan

【出处】

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GTAUF2014 & APSMHA2014第六届长城泌尿男科转化医学论坛暨第七届亚太男性健康与抗衰老研究学会年会

【发表日期】

：

2014年11期

【关键词】

：

Ring chromosome 4 oligospermia synapse complex recombination transcriptional ina

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Background: Ring chromosomes are often associated with spermatogenetic failure.However, the mechanism is poorly understood.We here reported a single man with severe oligospermia and a ring chromosome 4 with a microdeletion at 4p16.3.Methods: Synapsis (asSCP3), recombination (as MLH1)and transcriptional inactivation (as BRCA1) in a testicular biopsy were examined by fluorescence immunostaining.

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Meiotic prophase I defects in an oligospermic man with Wolf-Hirschhorn syndrome with ring chromosome

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