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Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is an effective and dependable, minimally invasive procedure to investigate mediastinal and hilar lymphadenopathy.However, recent case reports have shown that EBUS-TBNA is sometimes accompanied by severe infectious complications.Here, we report three cases with refractory febrile complications following EBUS-TBNA for intra-pulmonary large mass lesion of lung cancer (squamous cell carcinoma in two cases and adenocarcinoma in one).