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The aim of this study was to develop quercetin-loaded mixed micelles (Qu-MMs) by a film dispersion method with Poloxamer 407 (F127), D-α-tocopherol polyethylene glycol 1000 succinate (TPGS),and polyethylene glycol 15 hydroxystearate (HS-15) as carriers.The novel Qu-MMs were characterized by particle size, morphology, zeta potential, encapsulation efficiency, X-ray diffraction (XRD), and in vitro release.