Consequences of compromised mechanical coupling in desmoglein 2-mutant mice for cardiomyocyte functi

来源 :The 18th Congress of the International Federation of Associa | 被引量 : 0次 | 上传用户：zooton2009

【摘要】

：

【作者】

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Sebastian Kant Claudia A.Krusche Rudolf E.Leube

【机构】

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Institute of Molecular and Cellular Anatomy, R WTH Aachen University, Aachen, Germany

【出处】

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The 18th Congress of the International Federation of Associa

【发表日期】

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2014年8期

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Cardiomyocytes are attached to each other by multicomponent junctions at the intercalated disk.The resulting robust mechanical and functional coupling supports coordinated and highly adjustable cardiac contractility during the entire life time.Disturbance of desmosomes, which are part of the intercalated disk structure, has been implicated in arrhythmogenic right ventricular cardiomyopathy (ARVC).

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Consequences of compromised mechanical coupling in desmoglein 2-mutant mice for cardiomyocyte functi

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