Purpose: Aim of the study is to evaluate the role of professional and domestic oral hygiene sittings in preventing collateral effects of radiotherapy.Methods: The sample includes 26 patients affected by head and neck carcinoma,recruited before proceeding with radiotherapy; Patients are given two questionnaires,to evaluate their knowledge about oral hygiene manoeuvres and radiotherapy collateral effects.Before and after radiotherapy patients undergo: periodontal evaluation by means of the plaque index and PSR.basal and induced saliva flux evaluations.