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Objective:①To investigate the distribution of CYP17 polymorphisms in cytochrome P450c(P450)gene in postmenopausal Han women in Anhui as well as its correlation with bone mineral density(BMD) and serum lipid level of.radius.Methods:①CYP17 polymorphism of P450 gene were analyzed by polymerase chain reaction restriction fragment length polymorphism(PCR-RFLP) in 194 healthy postmenopausal Han women in Anhui.BMD at lumbar spine 2-4 and the femoral neck,Wards triangle and trochanter were measured by dual-energy X-ray absorptionmetry (DEXA) as well.