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蜕皮激素受体(ecdysone receptor,EcR)广泛存在于昆虫体内,是绿色农药设计的重要靶标1.双酰肼类化合物作用机制与天然蜕皮激素类似,通过与EcR 结合,启动与昆虫蜕皮相关的转录因子,但因其不易被清除,导致昆虫持续蜕皮,最终因饥饿、失水死亡.
QSAR和MM-PBSA在EcR蜕皮激动剂虚拟筛选中的应用
【摘 要】
：
蜕皮激素受体(ecdysone receptor,EcR)广泛存在于昆虫体内,是绿色农药设计的重要靶标1.双酰肼类化合物作用机制与天然蜕皮激素类似,通过与EcR 结合,启动与昆虫蜕皮相关的转录因子,但因其不易被清除,导致昆虫持续蜕皮,最终因饥饿、失水死亡.
【机 构】
：
中国农业大学理学院,农药分子设计与发现实验室 北京市海淀区圆明园西路2号,100193
【出 处】
：
中国化学会第十届全国化学生物学学术会议
【发表日期】
：
2017年10期
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