基于BODIPY染料靶向溶酶体的乏氧探针的构建

来源 :The First Asian Conference on Porphyrins, Phthalocyanines an | 被引量 : 0次 | 上传用户：mm963258

【摘要】

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　　乏氧是肿瘤细胞的一个重要特征。[1-2]乏氧会导致肿瘤中各种还原酶数量增加,如硝基还原酶(NTR)、偶氮还原酶等。其中硝基还原酶可将硝基还原为氨基。另外,BODIPY染料具有

【作者】

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邸麟婷周志宽盖立志卢华

【机构】

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杭州师范大学有机硅化学及材料技术教育部重点实验室,浙江杭州,311121

【出处】

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The First Asian Conference on Porphyrins, Phthalocyanines an

【发表日期】

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2019年11期

【关键词】

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BODIPY探针溶酶体乏氧细胞硝基还原酶

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论文部分内容阅读

　　乏氧是肿瘤细胞的一个重要特征。[1-2]乏氧会导致肿瘤中各种还原酶数量增加,如硝基还原酶(NTR)、偶氮还原酶等。其中硝基还原酶可将硝基还原为氨基。另外,BODIPY染料具有刚性共轭共平面结构,易于修饰,光物理化学性质优异。[3]目前基于BODIPY染料靶向溶酶体的探针已经被报道[4],但是靶向溶酶体并检测乏氧环境的BODIPY荧光探针仍然是一个挑战。

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基于BODIPY染料靶向溶酶体的乏氧探针的构建

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