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Objective Analysis of beryllium sulfate in BALB/C mice spleen lymphocyte proliferation function and influence of lymphocyte subgroup.Methods Mice were randomly divided into control group, BeSO4 infected 1ow(2.5 mg/kg), medium (5.0 mg/kg), high(10.0 mg/kg) dose group.Determined by MTT method to detect function of spleen lymphocyte proliferation in mice, Flow cytometry assay T lymphocyte subgroup.