【摘 要】
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Introduction:The defensins are small cationic and cysteine-rich molecules With molecular weights between 3-6 kDa and about 45 amino acids in length and impo
【机 构】
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SingaporeEyeResearchInstituteSingapore
【出 处】
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2008中国深圳蛋白质和多肽科学大会
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Introduction:The defensins are small cationic and cysteine-rich molecules With molecular weights between 3-6 kDa and about 45 amino acids in length and important for innate immunity.Based on the spatial distribution of the three cysteine intra-molecular bonds,mammalian defensins can be divided into two major groups termed alpha-and beta-defensins.Defensins are an important component of the innate immune system,which provides an initial antimicrobial barrier for mucosal surfaces such as the surface of the eye,oral tissues,the airways and lungs and also the skin.As antimicrobial agents they show activity against Gram positive and Gram negative bacteria,fungi,and enveloped viruses and also against bacteria that have demonstrated resistance to currently used antibiotics.
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