Introduction:PRRS and PCV2 are two of the most widely spread pathogens for swine in China [1] [2].These two viruses can cause severe losses in the nursery.Moreover,secondary bacterial infections like H.parasuis (HP) and Strep.suis can make the disease situation on the farm even more complex.This is a field observation from a farm in Jiangsu province in China on the reduction of losses and the use of antibiotics in the nursery after implementation of PRRS and PCV2 vaccination.