Increased generation of reactive oxygen species(ROS)and an altered redox status have long been observed in cancer cells,and recent studies suggest that this biochemical property of cancer cells can be
Blockade of the protein-protein interaction between the transmembrane programmed cell death 1 protein(PD-1)and its ligand PD-L1 emerges as a promising immunotherapy for treating cancers.Using the tech
Docking-based virtual screening of chemical databases against macromolecular targets has identified bioactive compounds for the potential treatment of diseases.Because of the restriction of scoring fu
RAF/MEK/ERK pathways and PI3K/PDK/AKT pathways are involved in the regulation of cell growth and survival and are frequently dysregulated in human cancers,such as leukemia,melanoma and lung cancer.
Thiols,as common sulfurating reagents,[1] have numerous drawbacks,such as metal poisoning,unpleasant odor,and apt oxidation,which impede their applications.To overcome these disadvantages,Na2S2O3 has
Poly(ADP-ribose)polymerase-1(PARP-1)is a nuclear enzyme involved in the detection and repair of DNA damage.The inhibition of PARP-1 has several potential therapeutic applications for drug discovery.In
A complete set of new phospate-caged photolabile nucleoside phosphoramidites were synthesized,and were then site-specifically incorporated into sense or antisense strands of a siRNA.Single caging modi