【摘 要】
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We evaluated the safety issues raised by the risk of p53TCR gene transfer-associated on/off-target toxicities in relevant mouse models of adoptive transfer.We provide evidence that an optimized high-a
【机 构】
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Department of Hematology and Oncology Johannes Gutenberg University Germany
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We evaluated the safety issues raised by the risk of p53TCR gene transfer-associated on/off-target toxicities in relevant mouse models of adoptive transfer.We provide evidence that an optimized high-affinity scTCR-specific for the broadly expressed tumor-associated antigen p53(264-272) can eradicate p53+A2.1+ tumor ceils in vivowithout inducing off-target or self-directed toxicities in humanized mouse models of adoptive T-cell transfer.These data strongly support the improved safety and therapeutic efficacy of high-affimity scp53TCR for TCR-based immunotherapy of p53-associated malignancies.
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