It has been suggested that the genetic architecture of schizophrenia involve the action of common variants of small to moderate effects and possibly also some rare variants with much larger effect sizes,while the relative contribution of different classes or mechanisms of genetic risk and their potential interaction are unknown.Recently,It has been reported that rare genetic variants in adenosine triphosphate (ATP)-binding cassette A13(ABCA13)increase susceptibility to schizophrenia,bipolar disorder and major depression.However,some of the rare variants are failed to be replicated in an independent sample set,and the copy number variants in the ABCA13 gene are found to show no evidence conferring risk of schizophrenia and bipolar disorder.We performed an association study between the common alleles at ABCA13 gene and schizophrenia in the Han Chinese population consisting of 488 schizophrenia patients and 506 healthy controls.7 SNPs(rs4917139,rs7804075,rs 1880738,rs2361519,rs4917152,rs3923511 and rs6955686)were genotyped and no association between patients and controls was detected either in the single-marker or the haplotype analyses(P>0.05).Our results demonstrated that common genetic variants at ABCA13 gene are unlikely to be related to the pathogenesis of schizophrenia in the studied Han Chinese population.