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Purpose To examine the expression of Angiotensin Ⅱ(Ang Ⅱ) and type Ⅰ, type Ⅱ receptors (AT1, AT2) in Tenons capsule fibroblasts after rabbit trabeculectomy, and investigate the role of Ang Ⅱ in human Tenons capsule fibroblasts (HTFs) proliferation, migration and phenotype transition.