Objective akayasusarteritis (TA) is a heterogeneous disease.We aimed to explore the clinical features in distinct ages and/or gender populations, to improve diagnosis of TA.Methods Weretrospectively analyzed manifestations and helpful tests in 53 TA patients.Results(1) Ratio of onset agein male and female was 1∶4; Age of male was (35±11) years and female was (28±11) years.Onset age in 17% patientswas aged over 40.Onset symptom of TA was chest pain or tightness in male and high blood pressure or dizziness in female.(2) Chest pain, tightnessand fever appeared also more in male, especially young men.Pulselessness were found in first-visit men aged over 40 (P <0.05, P <0.05).(3) Laboratory tests were no differences between male and femalegroups, but lower glumerular filtration rate was found in more male patients(P <0.05); (4)In imaginginvestigations, more male patients, mainly young male, had multiple vascular involvement(P <0.05); patients aged over 40had less renal artery, abdominal aortic and multiple vascularinvolvement(P <0.05, P <0.05, P <0.01) (5) Thoracic aorta involvement was independent risk factor of elevated blood pressure (P <0.05); ascending aorta involvement was independent risk factor of aortic regurgitation (P <0.01) and combined aneurysm formation (P <0.05).There were no independent risk factors of renal dysfunction.Conclusion Onset age of TA was older in male than in female patients, obvious clinical symptoms, severe complications, and diffuse vascular involvements were more likely found in male especially young male than that in femalepatients.Range of lesions of arteries wasrelatively localizedin patients aged over 40.We shouldpay more attention toearly diagnosis and treatment to young male patients.