Plant diseases caused primarily by bacterialpathogens are leading to severe losses for agriculture andhorticulture crop production worldwide, and constitute agreat threat to global food security.With the increasing severe problems of currently commercial pesticides, such as toxicityand resistance, novel pesticides discovery is of high importance to the modern agriculture.3-Phenylpropan-1-amines, as the amphetamine isomers, are an important class of molecules in bulk as well as fine chemicals.They can serve as versatile building blocks in the synthesis of pharmaceuticals, natural products and dyes.Synthesis and bioactivity evaluation of the target amines directly from inexpensive and readily available alkenes is an attractive approach, due to the atom economy and will cater to pesticide production.As a continued work, a novel and unprecedented linear-selective (l/b up to > 99 ∶ 1) hydroaminomethylation of styrenes was accomplished with a rhodium/tetraphosphorus ligandcatalytic system, which allows for an efficient synthesis of 3-Phenylpropylamines.The in vitro antibacterial activity of the target amines were investigated against a variety range of plant bacterialpathogens by tablet diffusion method under 100μg/mL.It has be observed that most of the amines show good to excellent inhibition against the Ralstonia solanacearum.