AIM: Homocysteine (Hcy) accelerates the senescence of endothelial progenitor cells or endothelial cells (ECs) via telomerase inactivation and length shortening.However, the underlying mechanism is unc
AIM: Atherosclerosis is a chronic inflammation disease which is initiated by endothelial cell injury.TNF-α is directly associated with chronic vascular inflammation.
AIM: The impaired vasodilation under diabetes is the main reason contributing to diabetes-associated vasculopathy.However,the role and the relevant mechanism of ZEB1/miR-200c feedback loop in diabetes
AIM: Pulmonary arterial hypertension (PAH) is a devastating cardiopulmonary disorder with significant morbidity and mortality in the patients with various lung and heart diseases.PAH is characterized
AIM: Pulmonary arterial hypertension (PAH) is a malignant vascular disease manifesting itself as sustained vasoconstriction,enhanced pulmonary circulation resistance, high pulmonary blood pressure, re
AIM: Angiogenesis plays a critical role in the progression cardiovascular disease, retinal ischemia or tumorigenesis.The proliferation, survival and migration of endothelial cells play an important ro
AIM: Endothelial cell senescence contributes to the endothelial dysfunction and the development of age-associated vascular disorders, including atherosclerosis.Moreover, recent studies have shown alte
目的:研究牛磺酸对大鼠缺血心肌血管新生的作用并探讨其作用机制.方法:选用健康雄性Wistar大鼠80只,随机分为4组(每组20只):缺血再灌注模型组,低、中、高剂量牛磺酸处理组.缺血再灌注模型组口服生理盐水10 mL/kg,每天1次,连续7d.低、中、高剂量牛磺酸处理组牛磺酸200 mg/kg、400 mg/kg和800 mg/kg,每天1次,口服给药,连续7d.采用大鼠心脏冠状动脉缺血再灌注的方
AIM: Glucagon-like peptide-1 (GLP-1) exerts its actions via activating GLP-1 receptor (GLP-1R).Our previous study showed reduced GLP-1R expression in SHR renal arteries.The present study investigated
Angiogenic factor with G patch and FHA domains 1 (AGGF1) is a newly identified proangiogenic protein, which plays an important role in vascular diseases and angiogenesis.However, its role in myocardia