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Aim HER-2 is an important oncoprotein which overexpression, found in more than 30% of breast cancers, is strongly associated with aggressiveness, chemoresistance, and poor prognosis.The purpose of the present study was to investigate the antiproliferative affects of acetyltanshinone II A (ATA) on HER-2 positive MDA-MB-453, SK-BR-3, and BT-474 breast cancer cells and to explore the underlying molecular mechanism of action.