【摘 要】
：
Objective: To explore the influence of estrogen on HCC and in depth analyzing the mechanism of estrogen suppresses hepatocarcinogenesis in a rat model.Methods: A total of 160 female SD rats were rando
【机 构】
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Department of Hepatic Surgery,Anhui Provincial Hospital,Hefei,China
【出 处】
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22nd Asia Pacific Cancer Conference(第22届亚太抗癌大会)
论文部分内容阅读
Objective: To explore the influence of estrogen on HCC and in depth analyzing the mechanism of estrogen suppresses hepatocarcinogenesis in a rat model.Methods: A total of 160 female SD rats were randomly distributed into four groups: ovariectomy (OVX), sham operation (Sham), ovariectomy followed by 30 μg/kg body weight/day 17α-Ethynylestradiol (EE2) supplementation(OVX + E), and sexually intact control (Ctrl) groups.All rats were treated intraperitoneally with diethylnitrosamine(DEN) at a dose of 100 mg/kg body weight and following N-nitrosomorpholine (NMOR) (100 ppm) in drinking water for 20 weeks to establish SD rat HCC model.Then, in depth analyzing the mechanism of protective role of estrogen in the initiation, development and metastasis of HCC from protein and nucleic acid two aspects by using ELISA, immunohistochemistry(IHC), RT-PCR based on the findings of above.
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