论文部分内容阅读
Magnolol, an active ingredient of the bark of Magnolia officinalis, has been reported to exert potent anti-epileptic effects via the GABAA receptor.The receptor also mediates sleep in humans and animals.The aim of this study was to determine whether magnolol could modulate sleep behaviors by recording EEG and electromyogram in mice.The results showed that magnolol administered i.p.at a dose of 5 or 25 mg/kg could significantly shorten the sleep latency, increase the amount of non-rapid eye movement (non-REM, NREM) and rapid eye movement (REM) sleep for 3 h after administration with an increase in the number of NREM and REM sleep episodes.