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A set of covalent chromatin modifications contributes to stable (i.e.epigenetic) gene regulation and cell-fate determination in multicellular organisms.Among such modifications,trimethylation of histone H3 at lysine 27 (H3K27me3),which is catalyzed by Polycomb repressive complex 2 (PRC2),is required for the stable repression of a set of genes including homeotic genes.