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OBJECTIVE Local perfusion of morphine causes an increase of extracellular ascorbic acid (AA) levels in nucleus accumbens (NAc) of freely moving rats.However, the path ways that regulate morphine-induced AA release in NAc are not clear.METHODS Using HPLC-ECD examine the effects of intraventral tegmental area (VTA) administration of GABAA agonist and antagonist on morphine-induced increases in AA of NAc.