【摘 要】
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Liver fibrosis results from an excessive deposition of extracellular matrix (ECM) proteins secreted by activated human hepatic stellate cells (HSCs).The tra
【出 处】
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中国科协青年科学家论坛暨2006年第二届新生病毒性疾病控制学术研讨会
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Liver fibrosis results from an excessive deposition of extracellular matrix (ECM) proteins secreted by activated human hepatic stellate cells (HSCs).The transdifferentiation process of quiescent into activated HSCs requires a complete reprogramming in gene expression, which is accompanied by an increased activity of various transcription factors.Recently, we identified one transcription factor, zinc finger protein 267 (ZNF267) and found that it plays an important role in the activation of HSCs to response to stress factors such as virus, alcohol or immune dysfunction.The ZNF267 gene has a TATA-less promoter with multiple transcription initiation sites.
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