Cyp 4A2,Apoa1,ANXA2 and DPYD are key proteinson genistein anti-fibrotic in rats

来源 :第12届生物毒素研究及医药应用学术大会 | 被引量 : 0次 | 上传用户:super_sxw777
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Objective: To investigate the molecular mechanism of genistein therapy on CCl4-induced liver fibrosis in rats by utilizing isobaric tags for relative and absolute quantitation (iTRAQ) coupled with liquid chromatography and electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS).
其他文献
The α9α 10 nicotinic acetylcholine receptor (nAChR) subtype is a recently identified target for the development of breast cancer chemotherapeutics and analgesics, particularly to treat neuropathic pai
会议
内皮细胞(endothelial cell,EC)是重要的多功能细胞,具有调节血管张力、纤溶、抗凝、炎症反应等重要生理活性功能。在引起EC损伤的诸多因素中,补体所扮演的角色越来越受到关注。补体在机体天然防御、免疫调控中发挥重要作用,但其在诸多病理生理情况下的过度激活会引发炎症和组织损伤,而EC成为重要的靶细胞和效应细胞。揭示补体对EC的作用有助于进一步认识相关炎症和组织损伤的机制。
会议
A new peptide precursor, termed Sj7170, was characterized from the venomous gland cDNA library of the scorpion Scorpiopsjendeki.Sj7170 was deduced to be a 62 amino acid peptide cross-linked by five di
Although rear-fanged snakes are often considered as non-threatening to humans, some species are lethal or medically hazardous.The toxin components and bioactivities of front-fanged snakes have been ex
A novel hirudin isoform 3 mimetic peptide, named peptide S2, has been prepared by introduction of a stearic acid modification.Peptide S2 exhibited superior inhibitory activity to hirulog-1 (Bivariludi
会议
The major symptoms of envenomed victims suffered from viper snakebite are usually attributed to blood bleeding effect of either local or systemic hemorrhage resulting from the action of integrin recep
Recently, a novel 47-residue polypeptide toxin SSD609 was purified from Scolopendra subspinipes dehaani venom and showed cardiomyocyte Iks currents inhibition.Here, chemically synthesized SSD609 was s
会议
2014年7月,在亚北极区白令海采集了香螺(Neptuneavaricifera)和一种未定种的海螺;在北极区楚科齐海采集了香螺(N.varicifera)、拉式锯齿鸟蛤(Serripeslaperousii)和一种未定种的双壳蛤样品.本研究应用液相色谱-串联质谱联用(LC-MS/MS)技术,对这些软体动物样品中可能存在的多种海洋生物毒素进行了分析.结果表明:仅在楚科齐海采集的拉式锯齿鸟蛤中检测到
[Objective] To investigate the thrombolytic and antiplatelet effects of a novel plasminogen activator from the venom ofGloydius brevicaudusviper (GBV-PA) in vitro and in vivo.[Methods] Thrombolytic ex
Intracellular Ca2+ overload plays a pivotal role in acute heart failure, which is induced by tentacle extract (TE) from jellyfish Cyaneacapillata.If an intervention that inhibits the increase of cytos