OLR1 is involved in fatty acid transport and binds and degrades the oxidized form of low-density lipoprotein.The objective of the study was to identify the association of gene diversity with milk performance and meat quality in Holstein dairy cattle and Qinchuan Beef cattle.In this study,three SNPs (g.9425C>T, g.9426A>G and g.10497 C>A) of OLRI gene with milk and health traits were analyzed in Israeli population.The SNPs g.9425C>T and g.9426A>G were in exon 5, and SNP g.10497 C>A was in the 3 untranslated region (UTR).Single SNP analysis showed that SNPs g.9425C>T and g.9426A>G had no significant association with any traits, while allele C of SNP g.10497 C>A had significant influence on high protein percentage and SCC in this population (P<0.05),which indicated that this SNP was associated with health trait of dairy cattle.In Qinchuan beef cattle,SNP g.10497 C>A was genotyped, and three genotypes were identified also.The results showed that C allele seemed to be associated with an increase in lion eye area and eye muscle depth traits compared with A allele.