【摘 要】
：
How the blood vasculature and organs integrate is an important issue in development as well as in disease.In teleosts, the developing head kidney, composed
【机 构】
：
DepartmentofLifeScience,TunghaiUniversity,Taichung,TaiwanDivisionofMolecularandGenomicMedicine,Natio
论文部分内容阅读
How the blood vasculature and organs integrate is an important issue in development as well as in disease.In teleosts, the developing head kidney, composed of the pronephric glomerulus and the interrenal gland, interacts closely with the dorsal aorta (DA) during organogenesis and angiogenesis.We found in zebrafish that the DA-head kidney interaction was disrupted in the endodermless sox32 mutant and morphant.In contrast, the head kidney in Sox32-deficient embryo remained tightly associated with posterior cardinal vein (PCV), while both tissues demonstrated severe convergence defects.Rescued endoderm formation in the sox32 morphant by a simultaneous knockdown of Odd-skipped-related 1 significantly alleviated convergence defects of head kidney, indicating the importance of endoderm for patterning migration of the head kidney.Surprisingly, the severely defective convergence of head kidney tissues in the sox32-deficient embryo was suppressed by either the cloche (clo) mutation or the knockdown of clo-regulated genes which led to a disruption of axial vasculature.It suggested that head kidney tissues converged toward the midline even in the complete absence of endoderm and endothelium, thus the severely defective convergence of head kidney in the endodermless embryo could be due to a spatial restriction by the venous endothelium.Our findings thus indicated a role of venous vasculature for patterning the head kidney.
其他文献
Migration of postmitotic neurons in the developing cortex along radial glial fiber is essential for the formation of cortical layers.Several neurological di
在构建工业微生物的过程中，我们需要一个能有效进行基因组规模的基因编辑的工具。通过将酿脓链球菌二型CRISPR-Cas9系统运用到大肠杆菌中，我们构建了一个靶向的、连续的多
Background: Microbial tolerance to different environmental stresses is of importance for efficient production ofbiofuels and biochemical.Such traits are often i
Halomonas strain TD01, a newly identified halophilic bacterium with its whole genome sequenced, proved to be a promising low-cost host for the production of
Sensing the environmental signals and making proper decisions are crucial for mammalian cells.A number of highly conserved signaling transduction kinase mod
丁醇是重要的大宗化学品,可通过产溶剂梭菌发酵生产.拜氏梭菌对秸秆类木质纤维素水解液的耐受性较好,但对水解液中己糖和戊糖的共发酵能力有待提升.我们改进了原有TargeT
The Sonic Hedgehog pathway plays important roles in mammalian inner ear development.Mutations of Shh, Smo and Gli3 lead to severe defects in mouse inner ear
Patterning of nervous system requires precise input of the spatial cue.In our study, we found that the deneddylation complex CSN determine neural competence
Unlike mammals and birds, teleost fish undergo external embryogenesis, and therefore their embryos are constantly challenged by stresses from their living e
Cenani-Lenz syndactyly syndrome (CLS) is an autosomal recessive skeletal disorder that results in malformation of the distal limb, commonly associated with