【摘 要】
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Adult T-cell leukemia/lymphoma (ATLL) is a malignant lymphoproliferative disorder caused by human T-cell leukemia virus type 1 (HTLV-1).HTLV-1 is endemic in south-western Japan and the Caribbean basin
【机 构】
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Department of Dermatology, University of Miyazaki Japan
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Adult T-cell leukemia/lymphoma (ATLL) is a malignant lymphoproliferative disorder caused by human T-cell leukemia virus type 1 (HTLV-1).HTLV-1 is endemic in south-western Japan and the Caribbean basin.HTLV-l-induced ATLL has been divided in 4: hematological subtypes as acute,lymphoma, chronic, and smoldering.Chronic and smoldering ATLL have a relatively good prognosis,even without treatment.These types can, however, evolve to acute ATLL, which has a poor prognosis:the median survival time (MST) after ATLL diagnosis is only 6 months.Specific skin lesions are caused by infiltration of the skin by the tumor cells and have been described in about half of patients with ATLL.We previously studied 124 cases of ATLL with specific skin lesions.
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