Introduction: Kerala is a state in South India, where suicide rate is remaining at a very high rate.Suicide rate of Kerala is 25.3/1Lakh while the National Suicide Rate in India is 10.9/1Lakh population (National and State Crime Records Bureau).Aims: To study the psycho-socio-demographic and clinical profile of 1300 suicide attempters.Design: Cross-sectional study.Methods: The sample consisted of 1300 suicide attempters referred to the Suicide Prevention Clinic of Government Medical College Hospital Kottayam, Kerala.Evaluation was made with a proper History, Physical Examination, Mental Status Examination and Psychological Assessment.A specially designed-Proforma was used to collect the psycho-socio-demographic and other variables.Subjects were diagnosed using International Classification of Diseases-10 Criteria.Results: The data were analysed statistically.Associations were found by making use of appropriate statistical method.Male gender was associated with Low socio-economic class, unskilled work and farming profession, past history of psychiatric relevance, outside-house as the site, methods of insecticide intake, hanging and odollum (a seed) poisoning, financial difficulty as the trigger, time of attempt 12 pm to 6 am, consumption of alcohol before attempt and diagnosis of severe depressive episode, recurrent depressive disorder, bipolar mood disorder, delusional disorder and acute psychotic episode.Age-group below 35 years, upper and middle socio-economic class, graduate and postgraduate education, unemployment, student-status, house as the site of attempt, drug over-dosage as the method, triggers as conflict, scolding, friction with spouse and examination failure and diagnosis of adjustment disorder, mild depressive episode, acute stress reaction and dysthymia were found to be associated with female gender.Conclusion: Male suicide attempters are having more of biological disorders while the female attempters are having more of stress-related disorders.