【摘 要】
：
Purpose: To evaluate the cilinical therapeutic effects of human umbilical cord mesenchymal stem cell transplantation in treatment of end stage liver disease.Methods: From October 2011 to December 2012
【机 构】
：
Chengdu Military General Hospital China
论文部分内容阅读
Purpose: To evaluate the cilinical therapeutic effects of human umbilical cord mesenchymal stem cell transplantation in treatment of end stage liver disease.Methods: From October 2011 to December 2012, 50 patients ofdecompensation cirrhosis signing the informed consent were enrolled to receive transplantation of UCMSCs and were observed the cilinical therapeutic effects in follow-up 24 weeks.Hepatoprotective, antiviral and other conventional treatment is essential.Results: No complications or specific side effects related to the procedure were observed.Bilirubin levels were during follow-up, the symptoms such as abdominal distension, oliguria, edema and other symptoms remissed significantly during the first 2-3 weeks, appetite increased than before surgery.At followup of 24 weeks, serum albumin (32.00±3.88 VS 37.06±4.59, P<0.05) and prealbumin (82.66±34.63 VS 120.12±47.86, P<0.05) of patients improved significantly compared with preoperation, yet the level of does not decrease obviously.MELD score (8.49±3.31 VS 7.57±2.97, P<0.05) of patients were markedly improved at 24 weeks after transplantation.The level of AFP does not increased significantly after the treatment (P>0.05).There were no signi*3fcant differences between the HBV group and other etiology group (P>0.05).It is shown that the final effect of end-stage liver disease is not different although the cause of the disease is different.There was no significant difference ofhemodynamic changes of portal and splenic vein by ultrasound examination (P>0.05).Conclusion:UCMSCs transplantation is a safe and effective method, which can effectively improve the clinical symptoms and liver function index, help to improve the quality of life of the patients.
其他文献
Objective: Even though many treatment strategies are tried for spinal cord injury in several centers, no successful treatment breakthrough has been reported so far.We have published many articles on s
The inhibitory molecular environment remarkably contributes to failure of mature CNS neurons to regenerate their axons after injury.Among the extrinsic factors, chondroitin sulfate proteoglycans (CSPG
The significant improvement of aesthetic medicine in recent years has been based on the more comprehensive knowledge in the pathophysiology of aging.Gradual reduction of tissue volume has been known t
Glioblastoma is the most common malignant primary brain tumor in adults.The aggressive growth manner makes eradication impossible even after extensive microsurgical resection along with current standa
3D organotypic epithelial structures can be engineered using primary or immortalised oral keratinocytes.However, their detailed quantitative histological characterisation in comparison with normal muc
Objective: Decompensate cirrhosis has no effective therapy to date.The effectiveness of treatment is limited for the cause and it is difficult to prevent the further development of liver cirrhosis.Met
Regulatory T cells (Treg) offer new immunotherapeutic options to control undesired immune reactions.To get deeper insights into the prospects for clinical translation of human Treg subsets, we studied
As one of the primary degenerative disease of nervous system, Alzheimers disease (AD) has a lack of effective drug treatment now, and most of the drugs must be long-term medication to maintain the AD
Tyrosine kinase with immunoglobulin and epidermal growth factor homology domain-2 (Tie2) is involved in modulation of the function of endothelial progenitor ceils (EPCs).Shear stress is an important n
The regulation of cardiac differentiation is critical for maintaining normal cardiac development and function.The precise mechanisms whereby cardiac differentiation are regulated remain tmcertain.Here