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Background: Inherited BRCA1/2 mutations confer elevated breast cancer risk.Knowledge of factors that can improve breast cancer risk assessment in BRCA1/2 mutation carriers is important because no effective early detection for breast cancers exists.Methods: A cohort of 1,575 BRCA1 and 856 BRCA2 mutation carriers was used to evaluate SNPs and haplotypes at ATM, BARD 1, BRIP 1, CTIP, MRE 11 a, NBS 1, RAD50, RAD51, TOPBP 1, and ZNF35 in breast cancer risk.Analysis was undertaken using the weighted cohort approach ofAntoniou et al.Results: The primary event of interest was diagnosis of breast cancer.In BRCA1, no associations were observed with ATM, BARD 1, BRIP 1, CTIP MRE 11, RAD51, or ZNF35.At RAD50, an association was observed for one haplotype with a false discovery rate adjusted p-value (pFDR)=0.043.At NBS1, statistically significant associations were observed for one haplotype (pFDR=0.027).At TOPBP, we observed a pFDR=0.027 for haplotypes.In BRCA2, although significant associations were observed with single SNPs, no haplotypes from any of the studied genes showed statistically significant associations with breast cancer risk.Discussion: Variants in genes that interact biologically with BRCA 1 and/or BRCA2 are associated with modified breast cancer risk in women who carry BRCA1/2 mutation.Validation was done on a number of SNPs through a separate CIMBA cohort and showed consistent results as the primary analysis.