Copper-Catalyzed Synthesis of Furo[3,2-c]coumarin And Dihydrofuro[3,2-c]coumarin Through Propargylat

来源 :中国化学会全国第十二届有机合成化学学术研讨会 | 被引量 : 0次 | 上传用户：huishouzhong2

【摘要】

：

【作者】

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Xiao-Yan Zhang Li-Li Hu Ze Shen Zhong-Zhu Chen Zhi-Gang Xu Shi-Qiang Li Jian-Wu Xie Hai-Lei Cui

【机构】

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Key Laboratory of the Ministry of Education for Advanced Catalysis Materials,Department of Chemistry

【出处】

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中国化学会全国第十二届有机合成化学学术研讨会

【发表日期】

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2015年7期

【关键词】

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cascade reaction 4-hydroxycoumarins propargyl acetates furo[3 2-c]coumarin 2 3-d

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　　A novel copper-catalyzed and microwave-promoted propargylation/alkyne oxacyclization/isomerization cascade for the synthesis of furo[3,2-c]coumarin in moderate to good yields(up to 80%yield)using readily available 4-hydroxycoumarins and terminal propargyl acetates as starting material has been developed.By switching the solvent DMSO to DCE,a range of 2-methylene-2,3-dihydrofuro[3,2-c]coumarin could be obtained in acceptable to good yields(up to 85%yield).

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Copper-Catalyzed Synthesis of Furo[3,2-c]coumarin And Dihydrofuro[3,2-c]coumarin Through Propargylat

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