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In order to explore the size effect of polymeric micelles on cellular internalization and tumor targeting,chrysin modified mPEG-PCL copolymer micelles with different particle sizes were fabricated to load Nile red as a fluorescence probe for intracellular and in vivo trafficking.Four kinds of micelles with the mean sizes of 20,40,80 and 120 nm and narrow size distributions were prepared.The zeta potentials of the micelles were ranged from -2 to 0 mV.