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  5. Functionalized PLGA-PEG nanoparticles conjugated with aptamer for targeting circulating tumor cells

Functionalized PLGA-PEG nanoparticles conjugated with aptamer for targeting circulating tumor cells

来源 :中国微米纳米技术学会纳米科学技术分会第三届年会暨2014全国纳米生物与医学学术会议 | 被引量 : 0次 | 上传用户：zhang16432780
【摘 要】
：
Targeted delivery of therapeutic nanoparticles have shown a significant feature in disease-specific manner compared with non-target nanoparticles.We have developed NPs formulated with poly(D,L-lactic-
【作 者】
：
Jian Liu Xiaobo Yu Qiao Tang Ting Chi Xiang Yang Jinwei Shao Lee Jia 
【机 构】
：
Cancer Metastasis Alert and Prevention Center,College of Chemistry Fuzhou University,State Key Labor
【出 处】
：
中国微米纳米技术学会纳米科学技术分会第三届年会暨2014全国纳米生物与医学学术会议
【发表日期】
：
2014年6期
【关键词】
：
Circulating tumor cells SYL3Captamer Ursolic acid nanoparticle Tumor metastasis 
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　　Targeted delivery of therapeutic nanoparticles have shown a significant feature in disease-specific manner compared with non-target nanoparticles.We have developed NPs formulated with poly(D,L-lactic-co-glycolic acid)-block-poly(ethylene-glycol)(PLGA-b-PEG)copolymer and decorated with an aptamer.The aptamer SYL3C can bind itself to the surface protein of circulating tumor cells(CTCs),epithelial cell adhesion molecule(EPCAM),which is overexpressed targeting ligand to promote the anti-tumor-metastasis delivery of Ursolic acid(UA).
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