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  5. BEX3 promotes cancer stemness and confers resistance to cisplatin via modulating OCT4 in nasopharyng

BEX3 promotes cancer stemness and confers resistance to cisplatin via modulating OCT4 in nasopharyng

来源 :第五届广州国际肿瘤学会议暨第一届中国抗癌协会肿瘤靶向治疗专业委员会年会 | 被引量 : 0次 | 上传用户：huntout
【摘 要】
：
　　Background: Nasopharyngeal carcinoma(NPC)can develop cisplatin-resistant phenotype.Research has revealed that enriched in cancer stem cell(CSC)population is
【作 者】
：
Wei Gao Siqi Chen Jimmy Yu-Wai Chan Thian-Sze Wong 
【机 构】
：
DepartmentofSurgery,TheUniversityofHongKong,HongKongSAR
【出 处】
：
第五届广州国际肿瘤学会议暨第一届中国抗癌协会肿瘤靶向治疗专业委员会年会
【发表日期】
：
2016年12期
【关键词】
：
Nasopharyngeal carcinoma Cisplatin Acquired resistance BEX3 OCT4 
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　　Background: Nasopharyngeal carcinoma(NPC)can develop cisplatin-resistant phenotype.Research has revealed that enriched in cancer stem cell(CSC)population is involved in developing cisplatin-resistant phenotype.CD271 is a candidate CSC maker in head and neck cancers.The CD receptor does not possess any enzymatic property.Signal transduction function of CD271 is mediated by the cellular receptor-associated protein.
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