Gsdmina3基因在小鼠上皮中对Frizzled表达的影响

来源 :中国细胞生物学学会2015年全国学术大会 | 被引量 : 0次 | 上传用户：lijing1671

【摘要】

：

　　Gsdmina3对于小鼠皮肤上皮细胞以及毛囊细胞的增殖、分化、凋亡等生理活动有着密切关系.Frizzled作为Wnt/β-catenin信号通路的受体会参与毛囊的形态建成以及毛囊周期的

【作者】

：

刘颖新白秀峰余裕连小华

【机构】

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第三军医大学细胞生物教研室,重庆,400038

【出处】

：

中国细胞生物学学会2015年全国学术大会

【发表日期】

：

2015年期

【关键词】

：

基因小鼠皮肤上皮细胞表达毛囊周期细胞的增殖形态建成信号通路

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论文部分内容阅读

　　Gsdmina3对于小鼠皮肤上皮细胞以及毛囊细胞的增殖、分化、凋亡等生理活动有着密切关系.Frizzled作为Wnt/β-catenin信号通路的受体会参与毛囊的形态建成以及毛囊周期的调控.Gsdmina3基因的突变将会出现毛囊的异常表型.Gsdmina3突变鼠(AE鼠)就具有异常的毛囊表型.本文分别从在体及离体两方面研究Gsdmina3基因下调和上调后,Frizzled表达情况的变化.

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Gsdmina3基因在小鼠上皮中对Frizzled表达的影响

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