术前伊马替尼治疗对局部晚期原发性胃肠道间质瘤的远期价值探讨

来源 :第十三届全国胃癌学术会议 | 被引量 : 0次 | 上传用户:jason008_xu
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  目的 评估不可切除或局部进展的胃肠道间质瘤术前服用伊马替尼的安全性及远期价值。方法 回顾性分析2009 年9 月至2016 年11 月于福建医科大学附属肿瘤医院术前口服伊马替尼间质瘤患者的临床病理分子资料,应用Kaplan-Meier 法比较3 年无病进展生存期和总生存率。
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胃和小肠是胃肠道间质瘤最常见的发病部位。胃胃肠道间质瘤的治疗手段以手术切除及分子靶向治疗为主,对传统化疗不敏感。我科收治一名胃恶性胃肠道间质瘤患者,基因检测显示为野生型(c-KIT 及PDGFRA 基因均未检测到突变),给予口服甲磺酸伊马替尼及苹果酸舒尼替均未获得缓解。经我院专家讨论后给予甲磺酸阿帕替尼治疗,复查CT 显示获得影像学部分缓解。