Synthesis and Biological Evaluation of Novel 9-Deazaxanthines-Based Derivatives as Potential Antiobe

来源 :第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 | 被引量 : 0次 | 上传用户:lkcxm
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  Thirty-one uracil-based derivatives were synthesized and preliminary screening by measuring glucose consumption in HepG2 cells,expression of adiponectin and leptin in 3T3-L1 adipocytes.Compound 8g showed the most potential activity and then chosen to be evaluated in HFD-Induced male Wistar rats.Compound 8g induced significant weight loss and regulated the serum levels of biochemical markers compared to metformin.8g could also improve glucose tolerance as determined by oral glucose tolerance test(OGTT) and intravenous glucose tolerance test(IGTT).
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