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5. Molecular mechanisms of the αβ and αγ heterodimers of human NAD-dependent isocitrate dehydrogenase

Molecular mechanisms of the αβ and αγ heterodimers of human NAD-dependent isocitrate dehydrogenase

来源 :中国生物化学与分子生物学会2019年全国学术会议 | 被引量 : 0次 | 上传用户：zhoumingjiang123

【摘 要】

：

Human NAD-dependent isocitrate dehydrogenase,existing as the α2βγ heterotetramer,catalyzes the decarboxylation of isocitrate into a-ketoglutarate in the Krebs cycle,which can be allosterically regulat

【作 者】

：

Pengkai Sun Tengfei Ma Yabing Liu Jianping Ding 

【机 构】

：

State Key Laboratory of Molecular Biology,Center for Excellence in Molecular Cell Science,Institute

【出 处】

：

中国生物化学与分子生物学会2019年全国学术会议

【发表日期】

：

2019年10期

【关键词】

：

Isocitrate dehydrogenase IDH NAD-IDH allosteric regulation conformational change 

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　　Human NAD-dependent isocitrate dehydrogenase,existing as the α2βγ heterotetramer,catalyzes the decarboxylation of isocitrate into a-ketoglutarate in the Krebs cycle,which can be allosterically regulated by citrate,ADP,ATP and NADH.

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