2. 您的位置
3. 首页
4. 会议论文
5. Akt-induced phosphorylation of Atg4B impairs mitochondrial activity and enhances the Warburg effect

Akt-induced phosphorylation of Atg4B impairs mitochondrial activity and enhances the Warburg effect

来源 :中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 | 被引量 : 0次 | 上传用户：JK0803_zouzhi

【摘 要】

：

Phosphorylation is a major type of post-translational modification,which can influence the cellular physiological function.Atg4B,a key autophagy-related protein,has a potential effect on the survival

【作 者】

：

Zhenhong Ni Jintao He Yaran Wu Xufang Dai Xiaojing Yan Bo Li Xinzhe Li Haojun Xiong Jiqin Lian Fengtian He 

【机 构】

：

Department of Biochemistry and Molecular Biology,College of Basic Medical Sciences,Army Medical Univ

【出 处】

：

中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议

【发表日期】

：

2018年10期

【关键词】

：

Akt Atg4B Phosphorylation Warburg effect HCC 

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Phosphorylation is a major type of post-translational modification,which can influence the cellular physiological function.Atg4B,a key autophagy-related protein,has a potential effect on the survival of tumor cells.However,it is still unknown as to the role of Atg4B phosphorylation in cancers.

其他文献

A proximity pabeling strategy reveals a new function of PAQR3 in ER-to-Golgi Transport

As a newly discovered tumor suppressor,PAQR3 is a Multifunctional protein.To identify the new potential functions,we applied a proximity labeling strategy exploiting APEX2-fused PAQR3 to biotinylate p

会议

Proximity-dependent labelingAPEX2PAQR3GolgiCOPII transport

Effects of Soybean Extracts on the protein expressions of MMP-9 and TIMP-1 in atherosclerotic plaque

[Objective]To investigate the effects of Soybean Extracts administration on the protein expression levels of matrix metalloproteinase-9(MMP-9)and tissue inhibitor of metalloproteinase-l(TIMP-l)in athe

会议

atherosclerosismatrix metalloproteinase-9tissue inhibitor of metalloproteinase

Cell-surface Translocation of Annexin A2 contributes to bleomycin-induced pulmonary fibrosis by medi

Bleomycin,a widely used cancer drug,may give rise to a serious side effect,pulmonary fibrosis which is associated with significant morbidity and mortality.Despite the intensive efforts,the precise pat

会议

Bleomycinannexin A2pulmonary fibrosisinflammationIL-6

Interleukin-22 promotes autophagy and inhibits apoptosis in rheumatoid arthritis through targeting t

Rheumatoid arthritis(RA)is a common chronic autoimmune inflammatory disorder.The role of autophagy and apoptosis in the pathogenesis of RA is intricate.Interleukin-22(IL-22)as a cytokine of Th22 plays

会议

Interleukin-22ApoptosisAutophagySTAT3Rheumatoid arthritis

Long noncoding RNA GACAT3 regulates fatty acid metabolism and promotes proliferation by acting as a

It is widely demonstrated that aberrantly expressed lncRNAs are associated with various cancers,but it is still uncertain how they may become coordinated during the gastric carcinogenesis.Here,we repo

会议

GACAT3competing endogenous RNAgastric cancer

Structure,Catalysis,and Inhibition of OfChi-h,the Lepidoptera-exclusive Insect Chitinase

Chitinase-h(Chi-h)is of special interest among insect GH18 chitinases due to its exclusive distribution in lepidopteran insects,one of the most destructive crop pests.Proteomic analysis of insect molt

会议

chitinasechitininhibitorPhlegmacin B1

Candida albicans secrete a small cysteine-rich protein Sel1 to trigger TLR2/4-dependent inflammatory

In spite of being a commensal for healthy individuals,Candida albicans can rapidly switch to pathogenic mode featured with hyphal development,altered cell wall composition and secreted virulence facto

会议

Decreased expression of subunit 3 of molecular chaperone TRiC suppresses proliferation of esophageal

OBJECTIVE: To investigate the value of subunit 3 of molecular chaperone TRiC(CCT3)to determine its function in esophageal carcinoma(EC)progression.METHODS: CCT3 expression levels were examined in EC c

会议

esophageal canrcinomaChaperonin Containing TCP1Subunit 3Cell proliferation

An engineered PD-1-based and MMP-2/9-oriented fusion protein exerts potent antitumor efficacy agains

Recent studies have shown that PD-1/PD-L1 checkpoint blockade is a dramatic therapy for melanoma through enhancing antitumor immune activity.Currently,major strategies for PD-1/PD-L1 blockade have mai

会议

PD-1/PD-L1MMP-2/9melanomatargeting proteinantitumor efficacy

细长聚球藻PCC7942的倍性分析

蓝细菌是一类古老的光合原核微生物，是原核生物中基因组低、中、高拷贝共存的典型物种之一。基于DNA荧光染色，发现细长聚球藻PCC 7942胞内DNA在特定时期会形成独立的类核区，统计分析表明其基因组拷贝数(倍性)在4-6之间。流式细胞仪分析发现，在延滞期，细长聚球藻PCC 7942基因组拷贝数迅速上升，在指数生长期和平台期，拷贝数不断下降。

会议

蓝细菌基因组拷贝数细胞分裂