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The serum and plasma proteome are desirable biological samples due to their accessibility and representative complexity.There is great hope that the investigation of these samples will lead to the discovery of new protein markers for disease diagnosis and therapeutic monitoring and novel drug targets.The tremendous complexity of the plasma proteome presents extreme analytical challenges in proteome characterization.Depletion of high-abundant proteins in serum and plasma has become routine and an accepted technique.These high-abundant protein components interfere with identification and characterization of important low-abundant proteins by limiting the dynamic range for mass spectral and electrophoretic analyses.