急性加重(AE)是导致慢性阻塞性肺疾病(COPD)患者住院和死亡的主要原因,但患者病情各异,针对不同的急性加重期慢性阻塞性肺疾病(AECOPD)患者,有必要根据实际临床情况进行个体化治疗。AECOPD患者的个体化治疗应建立在对急性加重原因的细致鉴别诊断、对合并疾病的正确处理和治疗药物的恰当运用等基础上。抗生素的选择、曲霉菌感染、糖皮质激素、合并肺高血压、急性肺栓塞、慢性心力衰竭和睡眠呼吸暂停综合征等的处理是AECOPD患者个体化治疗过程中应予关注的几个问题。 Acute exacerbation (AE) is the main cause of hospitalization and death in patients with chronic obstructive pulmonary disease (COPD), but patients with different conditions, for different acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients, it is necessary according to the actual clinical Individual treatment of the situation. Individualized treatment of AECOPD patients should be based on the careful diagnosis of the causes of acute exacerbations, the correct treatment of the combined diseases and the proper use of the therapeutic drugs. Antibiotic selection, Aspergillus infection, glucocorticoids, combined pulmonary hypertension, acute pulmonary embolism, chronic heart failure and sleep apnea syndrome and other treatment of patients with AECOPD should pay attention to several issues in the process of individualization.